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KMID : 0606019960020010053
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Soonchunhyang Journal of Industrial Medicine
1996 Volume.2 No. 1 p.53 ~ p.60
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Provocative Chelation Test with DMSA in Lead Workers
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Abstract
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To validate a provocative chelation test with 2,3-dimercaptosuccinic acid (DMSA) and to find out the practical urine collection time of chelation for industrial setting, 14 lead workers in secondary smelting industry and 5 office workers were
selected
for this study.
A single oral dose of 10 mg/kg DMSA were given to all subjects and urine was collected over the next 24 hours, urine volume and urinary lead concentration determined at 0, 2, 4, 6, 8, 10, 12, 24, hours.
Before oral administration of DMSA, blood lead, blood ZPP, urine delta-aminolevulinic acid (ALA) and hemoglobin of all subjects were also checked
@ES The results obtained as follows :
@EN 1. The mean blood lead of lead exposed workers was 49.7±13.7㎍/100ml and that of non-lead exposed workers was 5.7±1.3 ㎍/100ml. The mean value of blood ZPP and urine ALA was significantly higher than control, but there ws no difference of
mean
value in hemoglobin between lead exposed and non-exposed workers.
2. While mean urinary lead excretion before DMSA administration were 70±32 ㎍/liter and 129±72 ㎍/liter, it was increased 9.4 times with 659±306㎍/liter in non-lead exposed workers, but it was increased 3.14 times with 5922±2653 ㎍/liter.
3. To find out short time schedule for provocative chelation, correlation between 24 hours cumulative urine lead and other cumulative urine lead of short time such as 2, 4, 6, 8, 10, 12 hours revealed that correlation between 24 hours' urine
lead
and 4
hours' or 6 hours' urine lead was very high (r=0.930, r=0.981). it was concluded that 4 or 6 hours urine collection was quite enough for provocative chelation with DMSA.
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